Table 1.
PK parameters of whole-body organs
| Parameter | Tmax (min) | Cmax (%ID/organ) | T1/2 (min) | AUC0-t (%ID/organ × min) | VOI size (ml) |
|---|---|---|---|---|---|
| Liver | 37.6 ± 4.8 | 15.0 ± 1.2 | 388.0 ± 176.6 | 2,323.5 ± 172.8 | 1,559.4 ± 389.8 |
| Lung | 0.9 ± 0.0 | 31.0 ± 2.6 | 178.4 ± 30.9 | 1,584.3 ± 103.2 | 2,801.6 ± 324.5 |
| Brain | 18.7 ± 3.1 | 7.6 ± 1.1 | 274.3 ± 97.2 | 1,192.0 ± 153.9 | 1,519.0 ± 96.0 |
| Intestine | 140.8 ± 73.7 | 3.0 ± 1.3 | - | 455.9 ± 176.5 | 643.7 ± 183.1 |
| Stomach | 40.5 ± 73.9 | 1.5 ± 0.7 | 684.5 ± 519.5 | 235.3 ± 126.0 | 427.8 ± 203.2 |
| Heart | 0.9 ± 0.0 | 4.2 ± 1.4 | 276.0 ± 112.7 | 222.4 ± 43.5 | 640.0 ± 65.9 |
| Kidney | 0.9 ± 0.0 | 3.5 ± 0.7 | 383.1 ± 61.5 | 140.5 ± 18.3 | 357.4 ± 68.0 |
| Spleen | 2.6 ± 1.9 | 1.3 ± 0.5 | 301.5 ± 88.5 | 95.8 ± 29.0 | 177.9 ± 45.1 |
| Gallbladder | 105.7 ± 81.0 | 0.7 ± 0.3 | - | 85.4 ± 25.0 | 28.1 ± 10.7 |
| Urinary bladder | 129.9 ± 21.7 | 0.4 ± 0.2 | - | 66.6 ± 23.2 | 172.4 ± 36.3 |
Values are mean ± SD.