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Sabutoclax causes a G1-S phase cell cycle arrest. (a,c) Cell cycle analysis. (b,d) Percentage of cells analyzed in the subG1 phase, indicating cell death. E. Western blotting of whole cell lysates for Cyclin D1, Cyclin E, p27, p21, and phospho-Rb. EF1-α was used as a loading control. Data representative of three independent experiments.
