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. Author manuscript; available in PMC: 2016 Jan 15.
Published in final edited form as: Cell. 2015 Jan 15;160(0):88–104. doi: 10.1016/j.cell.2014.12.022

Figure 3. Decreased adiposity and increased energy expenditure in DKO mice.

Figure 3

a) Body weight, body length, b) tissue weights, c) body composition, and d) oxygen consumption, energy expenditure, ambulatory activity, RER, daily food intake and feeding efficiency in 8–10 week-old DKO and Ptpn1fl/flPtpn2fl/fl mice. e) Mice were administered leptin and body weights recorded. f) Fed plasma leptin levels. g–h) Hypothalamic gene expression in fasted mice injected IP saline, g) leptin, or h) insulin. Results are means ± SEM and are representative of at least 2 independent experiments; significance determined d–e, g–h) using two-way ANOVA.