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. 2015 Jun 4;3:33. doi: 10.1186/s40478-015-0210-6

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© Wheeler et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Tau4RTg2652 mice are immunoreactive for a variety of phospho-tau epitopes across multiple brain regions. At three months (a-e) and one year (f-j), AT8 immunoreactive neurons are numerous in the forebrain and hippocampus and moderately immunoreactive in the hindbrain. One year old mice demonstrate immunoreactivity to phospho-tau antibodies AT180 (k), AT270 (l) and PHF1 (m) in the CA1 region of the hippocampus. Scale bars = 500um (a-j)