Fig. 6.

Tau4RTg2652 animals exhibit mild alterations in behavior and motor abilities. (a) Tau4RTg2652 animals exhibit lower activity in the open field at 3 months. (b) Tau4RTg2652 animals rear more often than WT in the open field at 3 months. (c) Tau4RTg2652 animals are more active in the center area of the open field at both 3 and 6 months. WT animals shown as light grey bars, Tau4RTg2652 animals shown as dark grey bars. All graphs show the mean for each group, with both sexes and all testing groups pooled. Error bars show the standard deviation. For main effect of genotype at each age tested: *: p < 0.05 **: p < 0.01 ***p < 0.001. (d) Data shown are the mean of each animal’s daily average rotorod performance (3 trials per day). Error bars show the standard error of the mean. WT animals shown as open circles, Tau4RTg2652 animals shown as solid squares