Figure 1.

Activation of CB₁ induces chemotaxis in bovine CECs in a Boyden chamber assay. (A) The CB₁ agonist WIN55212-2 enhances bCEC migration in a concentration-dependent manner during a 3-hour incubation. This enhancement is fully blocked by the CB₁ antagonist SR141716 (SR1, 1 μM). (B) The endocannabinoid 2-AG induces a similar migration at the relatively low concentration of 100 nM. This migration is partly blocked by SR141716 (1 μM). *P < 0.05, unpaired t-test versus corresponding 100 nM drug.