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. 2014 Oct 16;112(2):357–364. doi: 10.1038/bjc.2014.543

Figure 2.

Figure 2

Effects of SMYD2 knockdown by siRNA (siRNA-SMYD2) compared with those of control siRNA (siRNA-Luc) in NUGC4 (wild-type TP53, A) and MKN28 (mutant TP53, B) cell lines. Top: effects of knocking down endogenous SMYD2 on cell proliferation at the indicated times. Results are mean±s.d. (bars) for quadruplicate experiments. The Mann–Whitney U-test was used for the statistical analysis: *P<0.05 vs siRNA-Luc-transfected cells. Middle: effects of siRNA-SMYD2 on the abundance of endogenous SMYD2 and p21 proteins 24–72 h after transfection of gastric cancer cell lines. Bottom: representative results of the population in each phase of the cell cycle in gastric cancer cell lines assessed by FACS 72 h after treatment with siRNA.