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VEGFR TKIs were associated with a significantly higher risk for all-grade QTc interval prolongation compared with no TKIs (RR=8.75, P<0.001, 95% CI 4.97–15.4). There was no evidence of heterogeneity (Q=10.55, P=0.879, I2=0.0%). The size of the squares indicates the weight of the study, and the diamond indicates the summary RR.
