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. 2014 Dec 16;112(2):329–337. doi: 10.1038/bjc.2014.589

Figure 6.

Figure 6

BCL-xL rescues NB4 cells from LBH589-induced apoptosis. (A) NB4 cells transduced with BCL-xL or the empty vector (mock) were treated with 1.5 mM VPA or 100 nM LBH589 (LBH) for 24 h. PI-stained cells were analysed by flow cytometry, the subG1 fractions (mean±s.e.m., n⩾3) are shown. Statistics were done with the two-tailed unpaired Student's t-test, *P⩽0.05, **P⩽0.01. (B) Transduced NB4 cells were treated as noted in (A). Immunoblot was probed with antibodies recognising BCL-xL, cleaved caspase-3, to ensure equal sample loading α-tubulin and HDAC1 were analysed.