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. 2014 Nov 25;112(2):338–344. doi: 10.1038/bjc.2014.590

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Copyright © 2015 Cancer Research UK

From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/

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Wound-healing assay to investigate the effect of PARVB knockdown on cell migration. (A) SAS cells without siRNA (control) and siPARVB SAS cells incubated for 0 and 72 h scratching the surface of confluent cells. PARVB knockdown decreased the migration rate and altered the cell morphology from spindle to round. (B) Magnified images of control and siPARVB cells at 72 h display the difference in cell morphologies. Left panel, SAS cells with expression of PARVB had sharp extensions of the cells at the edge of the wound; right panel, PARVB knockdown cells display a rounded morphology, possibly indicating cell transformation due to loss of PARVB expression.