Table 4. Multivariate analysis of variables associated with outcome in metaplastic breast carcinoma with and without inclusion of locally advanced cases.
|
All MBC cases |
MBC after excluding pT3&4 |
|||||||
|---|---|---|---|---|---|---|---|---|
| |
95%CI |
|
|
95%CI |
|
|||
| Hazard ratio | Lower | Upper | P-value | Hazard ratio | Lower | Upper | P-value | |
|
Breast cancer-specific survival | ||||||||
| TNM pT stage | 2.067 | 1.175 | 3.637 | 0.012 | 1.529 | 0.519 | 4.501 | 0.441 |
| LN stage | 1.463 | 0.808 | 2.649 | 0.209 | 2.156 | 1.044 | 4.455 | 0.038 |
| LVI | 1.666 | 0.649 | 4.278 | 0.289 | .984 | 0.258 | 3.746 | 0.981 |
| Chemotherapy | 0.305 | 0.143 | 0.650 | 0.002 | .359 | 0.140 | 0.920 | 0.033 |
| MBC subtype |
1.061 |
0.927 |
1.213 |
0.391 |
1.201 |
1.030 |
1.399 |
0.019 |
|
Disease-free interval | ||||||||
| TNM pT stage | 1.409 | 0.865 | 2.294 | 0.169 | 1.662 | 0.645 | 4.287 | 0.293 |
| LN stage | 1.284 | 0.739 | 2.229 | 0.375 | 1.486 | 0.750 | 2.944 | 0.256 |
| LVI | 1.393 | 0.545 | 3.558 | 0.488 | 0.593 | 0.144 | 2.438 | 0.468 |
| Chemotherapy | 0.570 | 0.288 | 1.127 | 0.106 | 0.605 | 0.273 | 1.341 | 0.216 |
| MBC subtype | 1.173 | 1.041 | 1.322 | 0.009 | 1.313 | 1.146 | 1.504 | 0.0001 |
Abbreviations: LN=lymph node; LVI=lymphovascular invasion; MBC=metaplastic breast carcinoma; TNM=tumour node metastasis.