Table 3. Main pharmacokinetic results in the thirteen patients under analysis.
| |
Cisplatin |
Paclitaxel |
||||||
|---|---|---|---|---|---|---|---|---|
| Patient | Cmax plasma (μg ml−1) | Cmax perfusate (μg ml−1) | Cmax tissue (μg g−1) | Cmax perfusate/Cmax plasma | Cmax plasma (μg ml−1) | Cmax perfusate (μg ml−1) | Cmax tissue (μg g−1) | Cmax perfusate/Cmax plasma |
| 1 |
1.50 |
22.41 |
NA |
14.91 |
<LOQ |
71.23 |
34.88 |
|
| 2 |
1.51 |
43.95 |
11.1 |
29.11 |
<LOQ |
86.08 |
20.22 |
|
| 3 |
2.04 |
47.22 |
26.9 |
23.18 |
<LOQ |
84.13 |
40.18 |
|
| 4 |
2.41 |
31.02 |
34.9 |
12.85 |
0.048 |
87.52 |
42.83 |
1823.33 |
| 5 |
1.42 |
28.32 |
NA |
19.97 |
<LOQ |
95.78 |
24.44 |
|
| 6 |
2.08 |
20.33 |
17.6 |
9.76 |
<LOQ |
56.1 |
68.334 |
|
| 7 |
2.03 |
22.69 |
25.1 |
11.20 |
0.068 |
72.0 |
41.85 |
1056.85 |
| 8 |
1.90 |
20.49 |
28.8 |
10.80 |
<LOQ |
64.6 |
15.774 |
|
| 9 |
1.83 |
20.23 |
NA |
11.05 |
0.063 |
63.3 |
40.2 |
1004.68 |
| 10 |
2.32 |
20.22 |
NA |
8.71 |
0.062 |
56.1 |
40.512 |
905.97 |
| 11 |
1.12 |
16.49 |
NA |
14.72 |
0.044 |
61.2 |
5.41 |
1390.91 |
| 12 |
2.11 |
16.70 |
19.0 |
7.91 |
0.050 |
52.0 |
4.51 |
1040.00 |
| 13 |
2.02 |
12.66 |
NA |
6.27 |
0.050 |
57.6 |
11.96 |
1152.00 |
| Mean±s.d. | 1.87±0.37 | 24.83±10.38 | 23.33±7.97 | 13.88±6.58 | 0.055±0.009 | 69.82±14.29 | 30.08±18.31 | 1196.25±315.67 |
Abbreviations: LOQ=limit of quantification (0.050 μg ml−1); NA=tissue not available.