FIG 1.

Bacterial community composition of the vaginal microbiota of girls and mothers sampled longitudinally. Each column in the dendrogram and heatmap represents the vaginal microbiota sampled from a single individual at a single time point. In total, 198 samples from 31 girls and 47 samples from 24 mothers are represented. The dendrogram represents the average linkage (UPGMA) hierarchical clustering of samples based on the Bray-Curtis dissimilarity matrix computed from Hellinger-standardized taxon abundance data. The colored bars below the dendrogram represent cluster group (top row) and sample type (second and third rows). Clusters are named to signify the most abundant taxon, when applicable: LC (Lactobacillus crispatus dominated; n = 87), LI (L. iners; n = 71), LG (L. gasseri; n = 22), LJ (L. jensenii; n = 8), Bifido (Bifidobacterium; n = 2), GV (Gardnerella vaginalis; n = 30), and Other (n = 25). The heatmap represents proportions (before Hellinger standardization) of the 25 overall most abundant taxa within each community, as indicated by the legend at top left. Sample type categories include girl/mother and premenarche/postmenarche (no menarche status is indicated for mother samples, in gray).