FIG 7 .

Low-dose ciprofloxacin therapy increases intracellular UPEC reservoirs. (A and B) E. coli UTI89 titers in C57BL/6 mouse urine (A) or bladders and kidneys (B) following a 1-week prophylactic treatment regimen with either ciprofloxacin or vehicle. (C) Gentamicin protection assays indicated the presence of intracellular E. coli reservoirs. The dotted line indicates the limit of detection. Means from at least two independent experiments are shown. Significance was determined using an unpaired, two-tailed t test. ns, not significant; *, P = 0.0148.