FIG 5 .

Antiviral effect of PO-heparin. (A) In vitro comparison of the inhibitory effects of heparin and PO-heparin (0.5 mg/ml) on the trans-infection ability of leukocytes treated before contact with NiV. The NiV titer was measured in an infectious center assay, and results are expressed as the percentage of inhibition compared to results in untreated cells. (B) Groups of 5 hamsters were either left untreated or treated daily by subcutaneous injections of PO-heparin (10 mg/kg) for 12 days. Animals were infected intraperitoneally with 500 LD₅₀s of NiV on the first day of treatment and followed for 3 weeks. The results are expressed as the percentage of surviving animals in each group. Survival was significantly increased in the group of treated animals. *, P = 0.017 (Mantel-Cox test).