TABLE 1 .
Prevalences in human and bird viruses of H5N1 HA mutations identified in a database search
| HA region | Category of mutation | Mutation in HA (H5 numbering) |
% of strains with mutation (no. of strains)a among: |
|
|---|---|---|---|---|
| Human viruses |
Bird viruses |
|||
| Head | Only in human viruses | H125Y | 4.3 (4) | 0 (0) |
| V131M | 1.1 (1) | 0 (0) | ||
| A134S | 1.1 (1) | 0 (0) | ||
| A134V | 1.1 (1) | 0 (0) | ||
| K152Q | 2.1 (2) | 0 (0) | ||
| N182K | 1.1 (1) | 0 (0) | ||
| A184G | 2.1 (2) | 0 (0) | ||
| T195I | 1.1 (1) | 0 (0) | ||
| S223N | 4.3 (4) | 0 (0) | ||
| S223I | 1.1 (1) | 0 (0) | ||
| More prevalent in human viruses than in bird viruses | N94D | 15.9 (15) | 3.4 (12) | |
| A127T | 2.1 (2) | 0.9 (3) | ||
| 128Δ | 52.1 (49) | 22.2 (76) | ||
| I151T | 52.1 (49) | 22.2 (76) | ||
| D154N | 30.9 (29) | 30.3 (104) | ||
| D154E | 1.1 (1) | 0.3 (1) | ||
| D154G | 2.1 (2) | 1.4 (5) | ||
| T188I | 3.2 (3) | 2.3 (8) | ||
| R189G | 1.1 (1) | 0.3 (1) | ||
| R189S | 1.1 (1) | 0.9 (3) | ||
| Q192H | 4.3 (4) | 2.0 (7) | ||
| More prevalent in bird viruses than in human viruses (control) | A184E | 4.3 (4) | 32 (110) | |
| A185E | 3.2 (3) | 12 (42) | ||
| A185T | 3.2 (3) | 3.2 (11) | ||
| L190I | 1.1 (1) | 24.1 (83) | ||
| Stalk | Only in human viruses | Q15H | 2.1 (2) | 0 (0) |
| K22R | 1.1 (1) | 0 (0) | ||
| K28R | 2.1 (2) | 0 (0) | ||
| K35R | 1.1 (1) | 0 (0) | ||
| K48E | 1.1 (1) | 0 (0) | ||
a
There were 94 human virus strains and 343 bird strains in this study.