TABLE 1 .
Known metabolites statistically overrepresented in the colon of E. coli/F. prausnitzii-diassociated mice compared to E. coli-monoassociated mice after TNBS-induced colitis
| Class | Metabolite | KEGG/PubChem ID no. | Dixenic/monoxenic intensity ratio | SEM | P value |
|---|---|---|---|---|---|
| Amino acids | Spermidine minor | C00315 | 7.675 | 0.69 | 0.009 |
| N-Acetylaspartic acid | SID 136743417 | 5.472 | 0.29 | 0.000 | |
| Quinic acid | C00296 | 3.682 | 0.30 | 0.019 | |
| O-Acetylserine | C00979 | 2.821 | 0.12 | 0.0005 | |
| Isothreonic acid | SID 103172351 | 2.220 | 0.17 | 0.047 | |
| Threonic acid | C01620 | 2.120 | 0.11 | 0.012 | |
| Homocystine | C01817 | 0.490 | 0.06 | 0.031 | |
| 2-Ketoisocaproic acid | C00233 | 0.402 | 0.05 | 0.003 | |
| Energy metabolites | Phosphoric acid | C00009 | 5.334 | 0.39 | 0.003 |
| Glucose-6-phosphate | C00092 | 2.354 | 0.11 | 0.005 | |
| Fructose-6-phosphate | C00085 | 2.0364 | 0.10 | 0.015 | |
| Glycerol | C00116 | 2.0206 | 0.07 | 0.003 | |
| β-Sitosterol | C01753 | 0.0449 | 0.13 | 0.020 | |
| Lipids and fatty acids | 4-Hydroxybutyric acid | C00989 | 3.277 | 0.16 | 0.000 |
| Palmitic acid | C00249 | 2.765 | 0.17 | 0.014 | |
| Caprylic acid | SID 11528290 | 2.637 | 0.12 | 0.001 | |
| Ethanolamine | C00189 | 4.854 | 0.22 | 0.000 | |
| Phytol | C01389 | 2.4277 | 0.15 | 0.015 | |
| Squalene | C00751 | 2.004 | 0.13 | 0.046 | |
| Phenolic acids | Idonic acid | SID 135170473 | 3.779 | 0.40 | 0.049 |
| trans-Sinapinic acid | C00482 | 2.618 | 0.14 | 0.003 | |
| Syringic acid | C10833 | 2.180 | 0.11 | 0.008 | |
| Malonic acid | C04025 | 2.131 | 0.14 | 0.037 | |
| 3-Phenyllactic acid | C05607 | 2.080 | 0.10 | 0.011 | |
| 3,4-Dihydroxyhydrocinnamic acid | SID 111677818 | 0.269 | 0.06 | 0.001 | |
| Pyrimidine | Pseudouridine | C02067 | 2.556 | 0.17 | 0.019 |
| Orotic acid | C00295 | 0.279 | 0.09 | 0.011 | |
| Sugars | Fructose | C00095 | 5.023 | 0.29 | 0.001 |
| Mannose | C00159 | 2.896 | 0.23 | 0.025 | |
| Glyceric acid | C00258 | 2.644 | 0.10 | 0.000 | |
| N-Acetyl-d-hexosamine | C03136 | 2.591 | 0.19 | 0.036 | |
| 1,5-Anhydroglucitol | C07326 | 2.484 | 0.18 | 0.027 | |
| β-Gentiobiose | C08240 | 2.423 | 0.11 | 0.003 | |
| Arabinose | C00259 | 2.356 | 0.11 | 0.005 | |
| Tagatose | SID 163300922 | 2.240 | 0.16 | 0.037 | |
| Ribonic acid | C01685 | 2.187 | 0.11 | 0.013 | |
| 2-Deoxyerythritol | SID 108236 | 2.002 | 0.11 | 0.023 | |
| Glucuronic acid | C00191 | 0.321 | 0.02 | 0.000 | |
| Glycero-guloheptose | SID 117585658 | 0.085 | 0.07 | 0.001 | |
| Raffinose | C00492 | 0.024 | 0.15 | 0.027 | |
| Inulotriose | SID 4849 | 0.004 | 0.03 | 0.000 | |
| Other | Indole-3-lactate | C02043 | 5.427 | 0.39 | 0.003 |
| Shikimic acid | C00493 | 2.220 | 0.13 | 0.017 | |
| Putrescine | C00134 | 0.487 | 0.05 | 0.015 |