FIG 6 .
Neutralizing capacity of MPER antibodies. (A) The ability of two MPER antibodies (listed on the right) to neutralize a panel of HIV-1, SIVcpz, and SIVgor strains (bottom) is shown. Numbers indicate IC50s (in micrograms per milliliter) from TZM-bl cells, averaged from three different experiments, with a heat map indicating the relative neutralization potency. The highest antibody concentration used was 10 µg/ml. (B) Conservation of 4E10 and 10E8 epitopes. An alignment of HIV-1, SIVcpz, and SIVgor Env protein sequences is depicted, with dots indicating identity to the HXB2 reference sequence. A logo plot denotes the conservation of individual amino acids, with the height of each letter indicating the proportion of sequences that contain the residue at that site. Contact residues of 4E10 (blue) and 10E8 (red) are highlighted above the alignment.