TABLE 2 .
Neutralization potency in primary chimpanzee CD4+ T cells
| Antibody | IC50 fora: |
|||
|---|---|---|---|---|
| HIV-1 SG3 |
SIVcpz MT145 |
|||
| μg/ml | nM | μg/ml | nM | |
| CD4-Ig | 0.02 ± 0.02 | 0.22 ± 0.22 | 6.02 ± 3.5 | 65.4 ± 38.0 |
| CD4-218.3-E51 | 0.04 ± 0.04 | 0.20 ± 0.20 | 3.74 ± 1.4 | 18.7 ± 7.0 |
| eCD4-Ig | <0.01 ± 0.0 | <0.10 ± 0.0 | 3.68 ± 1.1 | 38.3 ± 11.5 |
| eCD4-Igmim2 | <0.01b | <0.10 ± 0.0 | 5.86b | 61.0b |
| CD4-218.3-E51-mim2 | <0.01 ± 0.0 | <0.05 ± 0.0 | 3.93 ± 1.5 | 19.7 ± 7.5 |
| CD4-218.3-E51-T20 | <0.01 ± 0.0 | <0.05 ± 0.0 | 4.90 ± 4.4 | 24.5 ± 22.0 |
| VRC01 | 0.03 ± 0.03 | 0.20 ± 0.20 | >10 ± 0.0 | >66.7 ± 0.0 |
| 10E8 | ND | ND | 6.07 ± 1.82 | 40.5 ± 12.1 |
| iMab | ND | ND | 0.64 ± 0.41 | 4.3 ± 2.7 |
| LM52 | ND | ND | 0.68 ± 0.18 | 4.5 ± 1.2 |
| PRO140 | ND | ND | 2.33 ± 1.99 | 15.5 ± 13.3 |
| PRO140-10E8 | ND | ND | 0.75 ± 0.68 | 3.6 ± 3.2 |
a
Shown are average values from 3 donors ± standard deviations, except as noted. ND, not done.
b
Not applicable (only performed for 1 donor).