TABLE 2 .
Upstream regulator | Predicted activation state | z score | P value of overlap | Target molecules in data set |
---|---|---|---|---|
MAP3K7 (TAK1)a | Inhibited | −2.14 | 3.09E−05 | BIRC3, CH25H, IFIH1, ITGB1, MMP3, PTGS2, RGS2, TNFSF10, VHL |
TNFb | Activated | 2.04 | 1.89E−24 | ADM, ALCAM, AMH, ANGPT1, ANPEP, ANXA1, APLN, APOBEC3B, ATP2A2, BIRC2, BIRC3, BTG2, CAT, CAV1, CCND2, CD36, CDKN2A, CDKN2C, CEBPA, CEBPB, CH25H, COL3A1, COTL1, CSF1, CTNNB1, CYBA, CYLD, CYR61, DAG1, DDX58, DKK1, DMD, EGFR, EGR1, EMP2, ENPP2, FERMT1, FGFR1, GNAI1, GPR176, HPGD, ID1, IFIH1, IGFBP2, IGFBP4, IL1R1, IL4R, ITGAV, ITGB1, JAG1, JUNB, KITLG, KLF5, KLF6, LGALS3, LRP6, MET, MIF, MMP10, MMP14, MMP3, NEFH, NFKB1, NFKB2, NFKBIZ, NID1, NME1, NRIP1, PDGFRA, PDPN, PDX1, PHLDA1, PLK2, PMAIP1, PROK2, PSMB9, PTEN, PTGS2, RASD1, RBP1, RELB, RGS2, RGS5, ROBO1, SDC4, SERPINE2, SGK1, SHH, SIRT1, SNAI1, SOCS1, SOD2, SP3, STAT1, TAPBP, TEK, TFPI, TFPI2, TIMP3, TJP1, TNFRSF6B, TNFSF10, TRAF2, TRAF3, TRAF6, VEGFA, VEGFC, VIM, WLS, WTAP, YY1 |
CHUK (IKKα)b | Activated | 2.08 | 8.20E−07 | CEBPB, CH25H, COL18A1, CSF1, CYBA, ENPP2, JUNB, KLF5, MFAP5, MMP3, NFKB2, NID1, PTGS2, RBP1, RELB, SERPINE2, SGK1, VEGFA, VEGFC |
TRAF2a | Activated | 2.36 | 2.70E−06 | ADM, BIRC2, BIRC3, CDKN2A, CYLD, EGFR, ITGB1, LRRC16A, NFKB1, PLBD1, TRAF2 |
GSK3Ba | Activated | 2.45 | 8.34E−06 | ATP2A2, BIRC2, BIRC3, CTNNB1, GLI1, NFKBIZ, PDX1, PTGS2, SNAI1, SYN1, TNFSF10 |
CD40b | Activated | 2.02 | 3.22E−07 | ANPEP, BIRC3, CCND2, CSF1, IL4R, ITGB1, LGALS3, MET, MMP14, MMP3, NEFH, NFKB1, NFKB2, PSMB9, PTGS2, TAPBP, TNFSF10, TP53AIP1, TRAF2, VEGFA |
NFKB1c | 1.64 | 8.82E−09 | ANKRD1, BIRC3, BTG2, CCND2, CSF1, EGFR, EGR1, ENPP2, GNAO1, JAG1, MMP10, MMP3, NFKB1, NFKB2, NMI, PTGS2, RELB, SDC4, SOD2, STAT1, TNFSF10, TRAF2, VEGFA | |
MAP3K14 (NIK)b | 1.59 | 3.09E−05 | BIRC3, EGFR, NFKB1, PTEN, PTGS2, RELB, TNFSF10, TRAF3, YAP1 | |
NFKBIA (IκBα)a | 1.14 | 4.71E−18 | ANKRD1, BIRC2, BIRC3, BTG2, CCND2, CEBPB, CH25H, COL3A1, COL5A2, CSF1, CTNNB1, CYBA, DAG1, EIF4G2, ENPP2, ERAP2, GPR176, HMGA1, HOXB8, ITGB1, JUNB, KLF5, KRT18, MMP14, MMP3, NFKB1, NFKB2, NID1, PIK3R1, PTEN, PTGS2, RBP1, RELB, SDC4, SERPINE2, SGK1, SHH, SMAD4, SOD2, SORL1, TIMP3, TNFRSF10A, TNFSF10, TRAF2, VEGFA, VEGFC, WBP5, YAP1 | |
NFKB2a | 4.18E−02 | BIRC3, NFKB2, PTGS2, SOD2 | ||
HRASc | 0.61 | 3.19E−16 | ADM, AREG, ATP2A2, BTG2, CAV1, CCND2, CDKN2A, CDKN2B, CEBPB, COL18A1, COL3A1, COL5A2, CSF1, CTNNB1, EGFR, EGR1, EIF2D, FERMT2, FZD1, HNRNPA2B1, HOXB6, HRAS, HRASLS, IGFBP4, ITGAV, ITGB1, JUNB, KLF5, KRT18, MET, MMP14, MMP3, NID1, PDGFRA, PSMB9, PTEN, PTGS2, RARB, SERPINE2, SH3RF1, SIRPA, SMAD4, SNAI1, SOX5, SP3, SYN1, TIMP3, TNFRSF10A, TOM1, VEGFA, VIM, YAP1 | |
STAT3b | 0.18 | 5.14E−09 | ADM, AREG, CAT, CCND2, CDKN2A, CEBPA, CEBPB, COL3A1, EGR1, FERMT2, IFIH1, IL1R1, IL4R, JAG1, JUNB, MMP3, NFKB1, PEG10, PHLDA1, PMAIP1, PROK2, PSMB9, PTGS2, SERPINE2, SGK1, SHH, SNAI1, SOCS1, SOD2, STAT1, TFPI2, TNFSF10, VEGFA, VIM | |
CTNNB1 (β-catenin)c,d | 0.15 | 1.29E−12 | ACTA2, ALCAM, ALDH1A1, ANXA1, BAMBI, CCND2, CDKN2A, CDKN2B, COL27A1, CRAT, CRIP1, CTNNB1, CYR61, DKK1, EGFR, EPHA5, FGF20, FLOT2, GAP43, GLI1, GNAO1, GREM1, HHIP, HOXA5, IGFBP2, IL1R1, ISL1, ITGB1, KLF5, LGALS3, MMP14, MMP3, NPTX1, NRCAM, POLR2A, POLR2E, PTGS2, SERPINE2, SGK1, SHH, SNAI1, SOX5, TIMP3, TJP1, VEGFA, VIM, YAP1 | |
PTENc,d | −1.06 | 5.28E−09 | ADM, ANGPT1, ANXA1, BTG2, CA12, CDK10, CDKN2A, CDKN2B, CTNNB1, DEGS1, EGFR, FES, IGFBP2, IL4R, JAG1, KLF5, KLF6, LGALS3, MET, MMP14, MMP3, NFKB1, PIK3R1, PTEN, PTGS2, SDC4, SHH, SMAD4, SMARCA4, TNFSF10, TOM1, VEGFA, VEGFC | |
EGR1c | 1.68 | 2.15E−08 | ATP2A2, CAV1, CCND2, CSF1, EGFR, EGR1, JUNB, MMP14, NFKB1, PDX1, PTEN, PTGS2, SGK1, SNAI1, SOCS1, SOD2, SYN1, TNFSF10, VEGFA | |
PIK3R1c,d | −0.05 | 3.51E−05 | CCND2, PDGFRA, PDX1, PIK3R1, PTEN, PTGS2, SOD2, VEGFA, VEGFC | |
MAP3K1 (MEK)a | 1.19 | 3.96E−04 | BIRC2, BIRC3, COL3A1, EGR1, MMP3, PTGS2, TNFRSF10A | |
MAPK1 (ERK2)a | −0.58 | 8.90E−07 | ANPEP, APOL6, CAV1, CTNNB1, DDX58, EGLN3, EGR1, FES, IFIH1, ITGAV, JUNB, L3MBTL1, LGALS3, NMI, PAQR6, PSMB9, PTGS2, SIRT1, SNAI1, SPRY4, STAT1, TJP1, TMEM158, TNFSF10, VIM | |
VEGFAc | −1.90 | 7.38E−07 | ADAMTS1, ANPEP, CAV1, CDKN2A, CYB5B, CYR61, EGR1, ETS2, FGFR1, GRB10, ID1, IGFBP4, ITGB1, JUNB, NME1, PTGS2, SOD2, TEK, TFPI2, VEGFA | |
ID1c,d | −1.49 | 8.83E−04 | BMI1, CDKN2A, EGR1, MMP14, SNAI1, VIM | |
TRAF3b | −0.86 | 4.22E−05 | ADM, BIRC3, EGFR, LRRC16A, MET, NFKB2, NFKBIA, PLBD1, RELB | |
ERBB4c | 1.39 | 3.11E−09 | ACTA2, BTG2, CADM1, COL3A1, COL5A2, CTNNB1, EGFR, EGR1, ERBB4, GAP43, IGFBP4, NID1, PTGS2, SERPINE2, TIMP3 | |
PRKCDb | 1.17 | 1.08E−04 | BIRC2, BIRC3, CEBPB, GLI1, JUNB, KLF5, NFKB2, PTGS2, RELB, VEGFA | |
JUNBc,d | 0.82 | 2.40E−03 | CAV1, CDKN2A, ITGAV, JUNB, MMP10, MMP3, RELB, SGK1, SNAI1 |
ChIPed by bcl3 in CT1-expressing cells with a FDR of >10.
Not ChIPed by bcl3 in CT1-expressing cells.
ChIPed by bcl3 in CT1-expressing cells with FDR of <10.
bcl3 peak overlaps ENCODE bcl3 peak.