Table 1. Correlation between EGFR protein expression and EGFR copy number alteration in tissue microarray cores.
|
EGFR
FISH |
|||
|---|---|---|---|
| Low gene copy numbera (%) | High polysomy (%) | Gene amplification (%) | |
|
EGFR IHC | |||
| 0 | 354 (70.5) | 10 (45.5) | 3 (14.3) |
| 1+ | 68 (13.5) | 2 (9.1) | 1 (4.8) |
| 2+ | 52 (10.4) | 6 (27.3) | 4 (19.0) |
| 3+ | 28 (5.6) | 4 (18.2) | 13 (61.9) |
Abbreviations: EGFR=epidermal growth factor receptor; FISH=fluorescence in situ hybridization; IHC=immunohistochemistry; TMA=tissue microarray.
a
Include disomy, trisomy and low polysomy.; Of the 726 TMA cores (three cores for 242 cases), data of 545 cores were available because of tissue loss, inadequate hybridisation or failure of FISH.