Table 1. Tumour expression patterns of SMAD4, p53 and β-catenin.
|
β-catenin |
||||
|---|---|---|---|---|
| Total | High | Low | ||
| n=94 (%) | n=56 (59.6%) | n=38 (40.4%) | P | |
|
SMAD4 | ||||
| Positive | 56 (59.6) | 25 (44.6) | 31 (81.6) | 0.001 |
| Negative | 38 (40.4) | 31 (55.4) | 7 (18.4) | |
|
p53 | ||||
| Normal | 42 (44.7) | 20 (35.7) | 22 (57.9) | 0.04 |
| Aberrant | 52 (55.3) | 36 (64.3) | 16 (42.1) | |
There is a strong association between loss of SMAD4 expression and high expression of nuclear β-catenin (P=0.001) and there is an association between aberrant p53 expression and high expression of nuclear β-catenin (P=0.04)
P-value is based on two-sided Fisher's exact test.