Table 1A. Preliminary pharmacokinetic parameters of sorafenib following multiple doses of 400 mg per b.i.d. sorafenib in combination with 50 mg of cyclophosphamide and 2.5 mg of letrozole on Day 1 of Cycle 2.

Patient No.	AUC(0–12) (mg h l−1)	Cmax (mg l−1)
1	80.2	8.40
2	101	10.7
3	263	23.2
5	45.7	4.98
6	56.0	5.73
7	86.8	11.4
8	103	11.6
9	46.3	6.10
10	79.0	9.00
11	113	16.4
12	41.7	4.22
13	94.5	17.6
Geometric mean	82.7	9.77
Geometric s.d.	1.64	1.68