Table 1B. Preliminary pharmacokinetic parameters of cyclophosphamide following multiple doses of 50 mg od cyclophosphamide in combination of 2.5 mg of letrozole without (Day 5, Cycle 1) and after concomitant treatment (Day 1, Cycle 2) with multiple oral doses of 400 mg bid sorafenib.

	AUC(0–24) (mg h l−1)			Cmax (mg l−1)			t1/2 (h)
Patient No.	Cycle 1	Cycle 2	Ratio cycles 2/1	Cycle 1	Cycle 2	Ratio cycles 2/1	Cycle 1	Cycle 2
1	22.4	21.4	0.96	1.86	1.89	1.02	13.7	9.86
2	20.1	12.1	0.60	2.28	1.61	0.71	7.56	4.74
3	19.7	10.7	0.54	1.91	1.13	0.59	8.13	7.41
5	6.58	5.51	0.84	1.57	1.43	0.91	3.25	3.10
6	19.8	14.4	0.73	2.60	2.29	0.88	8.46	6.83
7	12.0	7.99	0.67	1.56	1.44	0.92	6.16	4.52
8	16.6	12.9	0.78	2.19	2.67	1.22	7.25	5.04
9	21.1	17.8	0.84	2.20	2.12	0.96	8.76	7.15
10	19.3	17.1	0.89	1.98	1.80	0.91	9.27	7.29
11	35.2	21.2	0.60	2.74	1.99	0.73	13.8	8.88
12	14.9	10.2	0.68	1.72	1.48	0.86	5.81	3.69
13	11.7	8.17	0.70	2.07	1.90	0.92	5.84	3.92
Meana	16.7	11.9	0.71	2.01	1.77	0.88	7.39	5.43
S.d.b	1.50	1.52	1.20	1.19	1.26	1.20	1.48	1.47

^aGeometric means.

^bGeometric s.d.