Table 2. Univariate and multivariate Cox proportional hazards analyses for disease-specific survival in association with miR34a expression for all three cohorts.
|
Cohort 1 (n=394; 189)a |
Cohort 2 (n=182; 22)a |
Cohort 3 (n=621; 53)a |
||||
|---|---|---|---|---|---|---|
| Variable | HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value |
|
Age | ||||||
| Univariate | ||||||
| <50 | 0.834 (0.62–1.12) | 0.2335 | 1.451 (0.82–2.58) | 0.2059 | 0.817 (0.49–1.35) | 0.435 |
| Multivariate | ||||||
| <50 | 0.807 (0.57–1.14) | 0.2268 | 1.402 (0.51–3.86) | 0.5131 | 0.900 (0.49–1.63) | 0.7261 |
| >50 | 1.00 | 1.00 | 1.00 | |||
|
Tumour size | ||||||
| Univariate | ||||||
| 2–5 cm | 1.756 (1.29–2.40) | 0.0014 | 3.781 (2.04–7.00) | <0.0001 | 2.2026 (1.22–3.38) | 0.0068 |
| >5 cm | 3.191 (2.16–4.71) | <0.0001 | 8.402 (3.9–18.09) | <0.0001 | ||
| Multivariate | ||||||
| <2 cm | 1 | <0.0001 | 1 | 0.0022 | 1 | 0.0006 |
| >2–5 cm | 1.772 (1.28–2.47) | 4.709 (1.74–12.73) | 1.517 (0.81–2.86) | |||
| >5 cm | 2.959 (1.97–4.44) | 5.608 (2.31–13.62) | ||||
|
Nodal status | ||||||
| Univariate | ||||||
| Negative | 0.438 (0.33–0.58) | <0.0001 | 0.352 (0.18–0.70) | 0.0031 | 0.350 (0.22–0.57) | <0.0001 |
| Multivariate | ||||||
| Positive | 1.00 | 1.00 | 1.00 | |||
| Negative | 0.549 (0.40–0.75) | 0.0002 | 0.640 (0.25–1.66) | 0.3597 | 0.295 (0.16–0.54) | <0.0001 |
|
ERα | ||||||
| Univariate | ||||||
| Negative | 1.512 (1.16–1.97) | 0.0024 | 1.391 (0.70–2.76) | 0.345 | 1.895 (1.17–3.06) | 0.009 |
| Multivariate | ||||||
| Positive | 1.00 | 1.00 | 1.00 | |||
| Negative | 1.396 (1.00–1.93) | 0.0439 | 1.247 (0.38–4.05) | 0.7139 | 1.259 (0.66–2.42) | 0.4889 |
|
PR | ||||||
| Univariate | ||||||
| Negative | 1.409 (1.07–1.85) | 0.0133 | 1.610 (0.81–3.19) | 0.1736 | 2.666 (1.59–4.47) | 0.0002 |
| Multivariate | ||||||
| Positive | 1.00 | 1.00 | 1.00 | |||
| Negative | 1.140 (0.84–1.54) | 0.3935 | 1.798 (0.55–5.84) | 0.3286 | 1.724 (0.89–3.36) | 0.1096 |
|
HER2 | ||||||
| Univariate | ||||||
| Negative | 0.863 (0.56–1.34) | 0.5144 | 0.511 (0.18–1.45) | 0.2060 | 0.601 (0.29–1.23) | 0.1627 |
| Multivariate | ||||||
| Positive | 1.00 | 1.00 | 1.00 | |||
| Negative | 0.685 (0.41–1.13) | 0.141 | 0.369 (0.11–1.19) | 0.0952 | 1.003 (0.47–2.16) | 0.9929 |
|
miR34a | ||||||
| Univariate | ||||||
| High | 0.632 (0.43–0.93) | 0.0199 | 0.393 (0.21–0.74) | 0.0034 | 0.545 (0.30–0.99) | 0.0479 |
| Multivariate | ||||||
| Low | 1.00 | 1.00 | 1.00 | |||
| High | 0.647 (0.43–0.98) | 0.0381 | 0.343 (0.12–0.99) | 0.0468 | 0.727 (0.35–1.5) | 0.4014 |
Abbreviations: CI=confidence interval; HR=hazards ratio.
The P-values are shown for a 20-year follow-up for Cohorts 1 and 2 and 148 months for Cohort 3. Bold entities indicate statistically significant P-values.
a
The number of patients in each cohort followed by number of patient deaths due to the disease.