Table 3. Univariate and multivariate Cox analysis of PSA relapse-free survival for verified prognostic markers.
| Marker | Univariate hazard ratio (95% CI) | P-value | Multivariate hazard ratio (95% CI) | P-value | n |
|---|---|---|---|---|---|
| ADAM9 | 1.03 (0.69–1.52) | 0.895 | 1.07 (0.70–1.62) | 0.752 | 208 |
| AKT1 | 1.20 (0.78–1.85) | 0.412 | 1.61 (1.01–2.54) | 0.043 | 208 |
| ALCAM | 0.72 (0.46–1.13) | 0.149 | 0.85 (0.52–1.38) | 0.502 | 223 |
| AR (nuclear) | 0.60 (0.37–0.95) | 0.029 | 0.70 (0.43–1.14) | 0.152 | 193 |
| AR (stromal) | 0.30 (0.17–0.53) | <0.001 | 0.32 (0.17–0.59) | < 0.001 | 196 |
| BCL2 | 1.04 (0.66–1.64) | 0.864 | 0.99 (0.62–1.59) | 0.979 | 220 |
| CB1R | 1.70 (1.10–2.62) | 0.017 | 1.45 (0.91–2.31) | 0.114 | 216 |
| CD10 | 1.55 (1.00–2.40) | 0.051 | 1.27 (0.79–2.05) | 0.319 | 205 |
| CD24 | 0.71 (0.44–1.15) | 0.161 | 1.08 (0.64–1.82) | 0.778 | 214 |
| CD138 | 1.20 (0.77–1.88) | 0.417 | 1.08 (0.67–1.75) | 0.741 | 210 |
| CRGA | 2.04 (1.03–4.04) | 0.042 | 1.85 (0.91–3.76) | 0.089 | 222 |
| CRISP3 | 0.76 (0.51–1.14) | 0.188 | 0.71 (0.47–1.09) | 0.118 | 203 |
| E-CADHERIN | 1.56 (1.06–2.29) | 0.023 | 1.34 (0.89–2.02) | 0.160 | 212 |
| EZH2 | 1.27 (0.86–1.87) | 0.229 | 1.48 (0.98–2.23) | 0.010 | 210 |
| ER-alpha (Epithelium) | 2.00 (0.87–4.60) | 0.100 | 1.03 (0.44–2.41) | 0.953 | 195 |
| ER-alpha (Stroma) | 1.34 (0.81–2.23) | 0.256 | 1.44 (0.81–2.57) | 0.218 | 195 |
| ER-beta (Epithelium) | 1.16 (0.74–1.84) | 0.515 | 0.88 (0.54–1.45) | 0.624 | 184 |
| ER-beta (Stroma) | 1.16 (0.67–2.02) | 0.598 | 0.83 (0.45–1.51) | 0.540 | 186 |
| HDAC2 | 1.18 (0.79–1.75) | 0.415 | 0.99 (0.65–1.51) | 0.961 | 205 |
| HSP27 | 0.81 (0.39–1.67) | 0.568 | 0.77 (0.35–1.70) | 0.520 | 212 |
| Ki-67/MIB1 | 1.43 (0.80–2.56) | 0.226 | 1.21 (0.64–2.28) | 0.552 | 223 |
| MUC1 | 1.05 (0.72–1.53) | 0.814 | 0.93 (0.62–1.40) | 0.722 | 224 |
| N-CADHERIN | 0.63 (0.37–1.06) | 0.080 | 0.66 (0.38–1.16) | 0.149 | 219 |
| NFkB | 2.47 (1.08–5.63) | 0.031 | 2.13 (0.76–5.93) | 0.150 | 222 |
| p21 | 1.72 (1.15–2.56) | 0.008 | 0.87 (0.54–1.40) | 0.556 | 214 |
| p27 | 0.58 (0.39–0.86) | 0.007 | 0.73 (0.48–1.11) | 0.137 | 210 |
| p53 | 1.33 (0.81–2.18) | 0.261 | 1.06 (0.63–1.80) | 0.822 | 224 |
| PSMA | 2.56 (1.66–3.94) | < 0.001 | 1.99 (1.24–3.20) | 0.005 | 186 |
| SPINK1 | 0.73 (0.30–1.80) | 0.501 | 0.80 (0.29–2.20) | 0.661 | 220 |
| Vimentin | 1.34 (0.89–2.03) | 0.163 | 1.32 (0.84–2.07) | 0.232 | 209 |
Abbreviations: CI=confidence interval; n.a.=not applicable; PSA=prostate-specific antigen.