Table 3. Comparison of pooled relative risks in men and women.
| Cancer site | Alcohol intake | N | Men Pooled RR (95% CI) | I2 | N | Women Pooled RR (95% CI) | I2 | Pa |
|---|---|---|---|---|---|---|---|---|
| Oral cavity and pharynx | Light | 12 | 1.20 (1.06–1.35) | 0 | 8 | 1.00 (0.78–1.27) | 51 | 0.165 |
| Moderate | 26 | 2.01 (1.69–2.40) | 73 | 9 | 1.67 (1.25–2.22) | 52 | ||
| Heavy | 21 | 5.33 (4.28–6.63) | 71 | 3 | 5.70 (3.75–8.66) | 0 | ||
| Oesophageal SCC | Light | 16 | 1.39 (1.11–1.74) | 61 | 8 | 1.14 (0.87–1.49) | 43 | 0.548 |
| Moderate | 28 | 2.25 (1.78–2.85) | 85 | 8 | 2.18 (1.42–3.35) | 72 | ||
| Heavy | 24 | 4.69 (3.49–6.31) | 88 | 3 | 8.32 (2.95–23.45) | 72 | ||
| Oesophageal AC and gastric cardia | Light | 3 | 0.94 (0.42–2.08) | 78 | 2 | 0.85 (0.63–1.14) | 0 | 0.858 |
| Moderate | 5 | 0.92 (0.46–1.86) | 76 | 2 | 0.62 (0.42–0.93) | 0 | ||
| Heavy | 6 | 1.17 (0.72–1.88) | 57 | 1 | 3.80 (0.89–16.32) | 0 | ||
| Stomach | Light | 14 | 1.00 (0.92–1.10) | 17 | 6 | 1.08 (0.76–1.54) | 73 | 0.817 |
| Moderate | 20 | 1.07 (1.00–1.14) | 2 | 5 | 0.90 (0.66–1.22) | 62 | ||
| Heavy | 12 | 1.20 (0.99–1.45) | 63 | 1 | 3.23 (0.80–13.07) | 0 | ||
| Colorectum | Light | 29 | 1.05 (0.95–1.16) | 44 | 23 | 0.95 (0.89–1.01) | 27 | 0.010 |
| Moderate | 36 | 1.21 (1.11–1.32) | 40 | 20 | 1.07 (0.99–1.16) | 32 | ||
| Heavy | 20 | 1.53 (1.30–1.80) | 70 | 4 | 1.24 (0.68–2.25) | 69 | ||
| Liver | Light | 10 | 1.05 (0.84–1.32) | 53 | 6 | 0.81 (0.59–1.12) | 26 | 0.953 |
| Moderate | 16 | 1.08 (0.88–1.32) | 57 | 8 | 1.24 (0.88–1.75) | 39 | ||
| Heavy | 11 | 1.59 (1.21–2.09) | 69 | 3 | 3.89 (1.60–9.48) | 10 | ||
| Pancreas | Light | 15 | 0.98 (0.86–1.11) | 46 | 13 | 0.93 (0.86–1.01) | 39 | 0.196 |
| Moderate | 20 | 1.08 (1.00–1.15) | 0 | 11 | 1.04 (0.93–1.17) | 51 | ||
| Heavy | 12 | 1.16 (1.06–1.27) | 0 | 4 | 1.17 (0.98–1.40) | 2 | ||
| Larynx | Light | 8 | 0.85 (0.61–1.19) | 51 | 3 | 0.89 (0.62–1.29) | 0 | 0.935 |
| Moderate | 21 | 1.50 (1.23–1.83) | 66 | 3 | 1.59 (1.06–2.38) | 0 | ||
| Heavy | 22 | 2.77 (2.15–3.57) | 83 | 1 | 1.55 (0.45–5.34) | 0 | ||
| Lung | Light | 17 | 0.86 (0.82–0.91) | 0 | 11 | 0.85 (0.77–0.93) | 59 | 0.828 |
| Moderate | 22 | 0.98 (0.89–1.08) | 60 | 11 | 1.01 (0.89–1.15) | 70 | ||
| Heavy | 14 | 1.14 (1.00–1.31) | 78 | 4 | 1.20 (0.75–1.92) | 65 | ||
| Malignant melanoma | Light | 3 | 1.19 (0.82–1.72) | 0 | 4 | 1.25 (1.13–1.38) | 0 | 0.844 |
| Moderate | 3 | 1.32 (0.90–1.92) | 0 | 3 | 1.27 (1.14–1.43) | 0 | ||
| Heavy | – | n.e. | n.e. | – | n.e. | n.e. | ||
| Bladder | Light | 9 | 1.13 (0.97–1.32) | 32 | 7 | 0.88 (0.70–1.12) | 52 | 0.055 |
| Moderate | 12 | 1.07 (0.95–1.22) | 23 | 6 | 0.93 (0.72–1.20) | 44 | ||
| Heavy | 5 | 1.24 (0.87–1.78) | 70 | 1 | 0.81 (0.38–1.73) | 0 | ||
| Kidney | Light | 10 | 0.99 (0.87–1.11) | 30 | 9 | 0.85 (0.78–0.92) | 0 | 0.133 |
| Moderate | 10 | 0.83 (0.71–0.97) | 46 | 6 | 0.65 (0.52–0.81) | 42 | ||
| Heavy | 3 | 0.88 (0.29–2.63) | 65 | – | n.e. | n.e. | ||
| Non-Hodgkin's lymphoma | Light | 7 | 0.96 (0.78–1.18) | 50 | 8 | 0.90 (0.78–1.04) | 62 | 0.065 |
| Moderate | 9 | 0.91 (0.76–1.08) | 47 | 5 | 0.86 (0.72–1.03) | 44 | ||
| Heavy | 2 | 0.87 (0.52–1.43) | 0 | – | n.e. | n.e. |
Abbreviations: AC=adenocarcinoma; CI=confidence interval; n.e.= not evaluable; RR=relative risk; SCC=squamous cell carcinoma.
Only cancer sites for which more than 10 studies were available were considered.
a
Heterogeneity test.