Table 3. Univariate and multivariate Cox proportional hazard regression analyses of overall survival.

	Hazard ratio (95% confidence interval)
	Univariate		Multivariate
Variables		P value		P value
Clinical
Gender		0.768
Male	Reference
Female	0.942 (0.548–1.559)
Age, years		<0.001		<0.001
<65	Reference		Reference
⩾65	2.146 (1.507–3.055)		2.425 (1.662–3.537)
Body mass index, cm kg−2		0.015		0.093
<25	Reference		Reference
⩾25	0.591 (0.386–0.903)		0.687 (0.444–1.064)
American Society of Anesthesiologists score		0.086
1	Reference
⩾2	1.357 (0.953–1.924)
Year of surgery		0.743
1999–2006	Reference
2007–2011	1.063 (0.739–1.527)
Pathological
pT stage		<0.001		<0.001
⩽pT2	Reference		Reference
⩾pT3	3.730 (2.601–5.349)		2.567 (1.653–3.984)
Tumour grade		0.007		0.951
Low grade	Reference		Reference
High grade	2.151 (1.236–3.745)		0.980 (0.518–1.854)
Lymphovascular invasion		<0.001		0.143
Absent	Reference		Reference
Present	2.658 (1.890–3.739)		1.359 (0.901–2.051)
Margin status		<0.001		0.033
Negative	Reference		Reference
Positive	2.607 (1.602–4.242)		1.756 (1.047–2.946)
pN stage		<0.001		<0.001
N−	Reference		Reference
N+	3.133 (2.204–4.454)		2.194 (1.491–3.226)
Inflammatory
C-reactive protein, mg l−1		0.742
0 (⩽10)	Reference
1 (>10)	1.095 (0.637–1.884)
Albumin, g l−1		<0.001		0.047
0 (⩾35)	Reference		Reference
1 (<35)	2.961 (1.924–4.555)		1.670 (1.007–2.767)
White cell count, 109 l−1		0.345
0 (⩽11)	Reference
1 (>11)	1.412 (0.690–2.886)			0.508
Neutrophil count, 109 l−1		0.031	Reference
0 (<7.5)	Reference		1.243 (0.652–2.368)
1 (⩾7.5)	1.839 (1.057–3.200)
Lymphocyte count, 109 l−1		0.002		0.001
0 (⩾1.0)	Reference		Reference
1 (<1.0)	2.465 (1.410–4.311)		2.700 (1.511–4.825)
Platelet count, 109 l−1		<0.001		0.027
0 (<400)	Reference		Reference
1 (⩾400)	2.780 (1.597–4.842)		2.022 (1.082–3.779)