Figure 1.

Summary of the protocol. For all patients with positive findings at 3 months, the final decision about treatment, including the option of cystectomy, was taken according to disease status and the patient's preference. Fourteen percent cases did not receive immediate MitC post-TUR. BCG maintenance schedule consisted of three weekly instillations of Oncotice at 3 months and every 6 months thereafter (for 2–3 years depending on tolerance). *According to physician advice and patients choice. Abbreviations: BRB=bladder random biopsies; TUR=trans urethral resection.