Table 1. Association of clinical and histological variables with substaging (T1a vs T1b).

	T1a	T1b	Total	P
Age (years) (<70/⩾70)	44/45	52/59	96/104	0.78
Gender: Male/Female	79/10	100/11	179/21	0.82
Tumour size: <3 cm/>3 cm	55/34	59/52	114/86	0.14
Tumour number: solitary/multiple	49/40	60/51	109/91	>0.99
Tumour pattern: papillary/solid	84/5	82/29	166/34	0.0001
Lymphovascular invasion: yes/no	1/88	6/105	7/193	0.09
Micropapillarya: yes/no	3/86	12/99	15/185	0.06
Squamous metaplasia: yes/no	21/68	40/71	61/139	0.06
CISa: yes/no	17/72	40/71	57/143	0.01
CIS in prostateb: yes/no	0/79	7/93	7/172	0.02

Abbreviation: CIS=carcinoma in situ.

Subjects with T1b disease presented with significantly higher rates of solid pattern, associated bladder CIS and prostate CIS.

^a133 Patients underwent random bladder biopsies.

^bOnly evaluated in male patients.