Table 2. Univariate analysis for association of clinically and pathologically relevant variables with time to recurrence and time to progression.
|
Recurrence |
Progression |
|||
|---|---|---|---|---|
| Hazard ratio (95% CI) | P | Hazard ratio (95% CI) | P | |
| Age (years) <70/⩾70 | 0.5 (0.29, 0.86) | 0.01 | 0.59 (0.29, 1.22) | 0.15 |
| Gender: Male/Female | 0.81 (0.37, 1.78) | 0.59 | 1.09 (0.33, 3.59) | 0.89 |
| Tumour size: <3 cm/>3 cm | 0.59 (0.35, 0.99) | 0.04 | 0.44 (0.22, 0.91) | 0.02 |
| Tumour number: solitary/multiple | 0.68 (0.40, 1.14) | 0.14 | 0.66 (0.33, 1.34) | 0.25 |
| Tumour pattern: papillary/solid | 0.76 (0.39, 1.47) | 0.41 | 0.37 (0.17, 0.78) | 0.006 |
| Lymphovascular invasion: yes/no | 2.63 (0.95, 7.27) | 0.06 | 3.11 (0.94, 10.28) | 0.06 |
| Micropapillary*: yes/no | 0.69 (0.23, 2.21) | 0.53 | 0.99 (0.24, 4.19) | 0.99 |
| Squamous metaplasia: yes/no | 1.18 (0.68, 2.04) | 0.57 | 1.00 (0.46, 2.17) | 0.99 |
| CIS: yes/no | 0.71 (0.41, 1.25) | 0.23 | 0.23 (0.46, 2.17) | <0.0001 |
| CIS in prostate: yes/no | 0.84 (0.20, 3.44) | 0.80 | 0.45 (0.11, 1.88) | 0.26 |
| Substaging: T1a/T1b | 0.61 (0.36, 1.04) | 0.07 | 0.21 (0.08, 0.54) | 0.0004 |
Abbreviations: CI=confidence interval; CIS=carcinoma in situ. *Any % of micropapillary component. P<0.05 represent statistically significant values (shown in bold).