Table 4a. Univariate analysis for progression; association of substaging, tumour pattern, size and whether patients had CIS with time to progression at 2 and 5 years (only showing variables with significant P-values).
| N | Prog | Progression free at 2 years | Progression free at 5 years | Hazard ratio and 95% CI | P | |
|---|---|---|---|---|---|---|
| Substaging | 0.0004 | |||||
| T1a | 89 | 5 | 0.95 (0.90, 0.99) | 0.80 (0.71, 0.86) | 0.21 (0.08, 0.54) | |
| T1b | 110 | 26 | 0.81 (0.72, 0.87) | 0.74 (0.61, 0.83) | 1 (reference) | |
| Tumour pattern | 0.006 | |||||
| Papillary | 165 | 21 | 0.91 (0.85, 0.94) | 0.87 (0.80, 0.92) | 0.37 (0.17, 0.78) | |
| Solid | 34 | 10 | 0.73 (0.55, 0.85) | 1 (reference) | ||
| Tumour size | 0.04 | |||||
| <3 cm | 113 | 12 | 0.91 (0.84, 0.95) | 0.87 (0.75, 0.93) | 0.59 (0.35, 0.99) | |
| >3 cm | 86 | 19 | 0.83 (0.73, 0.90) | 0.76 (0.64, 0.85) | 1 (reference) | |
| CIS | <0.0001 | |||||
| Yes | 56 | 18 | 0.71 (0.57, 0.81) | 0.60 (0.39, 0.76) | 1 (reference) | |
| No | 143 | 13 | 0.94 (0.89, 0.97) | 0.90 (0.83, 0.95) | 0.23 (0.11, 0.48) |
Abbreviations: CI=confidence interval; CIS=carcinoma in situ. P<0.05 represent statistically significant values (shown in bold).