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. 2014 Dec 23;112(3):468–474. doi: 10.1038/bjc.2014.633

Table 4c. Combined risk for the association of T1b, larger tumour size and associated CIS.

  Hazard ratio and 95% CI P
Substaging (T1a) 0.25 (0.12, 0.52) 0.0002
CIS (no) 0.28 (0.11, 0.73) 0.009
Size (<3 cm) 0.40 (0.19, 0.84) 0.014

Abbreviations: CI=confidence interval; CIS=carcinoma in situ. P<0.05 represent statistically significant values (shown in bold).