Table 2. IHC staining of six biomarkers in the K-RAS/Ki67/HIF-1α pathways.
| Biomarker | Total samples stained | Positive samples | Total patients stained | Positive patients | Median expression, range of positive samples |
|---|---|---|---|---|---|
| EGFR | 249 | 192 (77%) | 110 | 94 (85%) | 2 (0–4) |
| HER2 | 287 | 56 (19%) | 117 | 32 (27%) | 0 (0–2) |
| pERK | 301 | 219 (72%) | 131 | 106 (81%) | 40% (5–90%) |
| SIAH | 315 | 303 (96%) | 127 | 127 (100%) | 30% (5–90%) |
| Ki67 | 250 | 237 (95%) | 119 | 118 (99%) | 40% (5–90%) |
| HIF-1-α | 210 | 143 (69%) | 100 | 77 (77%) | 40% (2–90%) |
Abbreviations: HIF-1α=hypoxia-inducible factor 1α; IHC=immunohistochemical.