Figure 2.

Progression-free survival (A and B) and overall survival (C and D) from treatment initiation in patients treated by alkylating agents. In A and C, patients are compared with MGMT promoter methylation in tumour tissue, assessed by pyrosequencing (group 1: patients with methylated MGMT; group 2: patients with unmethylated MGMT). In B and D, patients are compared according to MGMT protein expression, assessed by immunohistochemistry (group 1: patients with MGMT-negative tumours; group 2: patients with MGMT-positive tumours).