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. 2015 Jan 13;112(3):523–531. doi: 10.1038/bjc.2014.660

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Copyright © 2015 Cancer Research UK

From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/

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Progression-free survival (A and B) and overall survival (C and D) from treatment initiation in patients treated by alkylating agents. In A and C, patients are compared with MGMT promoter methylation in tumour tissue, assessed by pyrosequencing (group 1: patients with methylated MGMT; group 2: patients with unmethylated MGMT). In B and D, patients are compared according to MGMT protein expression, assessed by immunohistochemistry (group 1: patients with MGMT-negative tumours; group 2: patients with MGMT-positive tumours).