Table 1. MGMT status in 107 neuroendocrine tumours.
Tumour location |
Histological grade |
|||||||
---|---|---|---|---|---|---|---|---|
All patient (n=107) | Pancreas (n=62) | GI tract (n=33) | Lung (n=5) | Other (n=7) | G1 (n=41) | G2 (n=57) | G3 (n=9) | |
MGMT promoter methylation, MS-PCR | P | 0.11 | 0.17 | |||||
Non-interpretable | 8 | 7 | 0 | 0 | 1 | 6 | 1 | 1 |
Non-methylated | 87 | 51 | 27 | 5 | 4 | 32 | 48 | 7 |
Methylated | 12 | 4 | 6 | 0 | 2 | 3 | 8 | 1 |
MGMT promoter methylation, pyrosequencing | P | 0.41 | 0.12 | |||||
Non-interpretable | 8 | 7 | 0 | 0 | 1 | 6 | 1 | 1 |
Non-methylated | 75 | 40 | 27 | 1 | 4 | 29 | 41 | 5 |
Methylated | 24 | 15 | 6 | 4 | 2 | 6 | 15 | 3 |
MGMT protein expression, immunohistochemistry | P | 0.45 | 0.64 | |||||
Non-interpretable | 18 | 12 | 4 | 2 | 0 | 8 | 10 | 0 |
Positive | 60 | 32 | 22 | 2 | 4 | 24 | 30 | 6 |
Negative | 29 | 18 | 7 | 1 | 3 | 9 | 17 | 3 |
Abbreviations: GI=gastrointestinal; MGMT=O6-methylguanine-DNA methyltransferase; MS-PCR=methyl-specific PCR.