Table 3. Univariate and multivariate Cox logistic regression analyses for the prediction of NSCLC patients' OS course.
| Variable | HR | 95% CIa | P-value | HR | 95% CIa | P-value |
|---|---|---|---|---|---|---|
| Univariate | Multivariate | |||||
|
miR-197 | ||||||
| Low | 1.00 | 1.00 | ||||
| High | 2.31 | 1.44–3.73 | 0.001 | 2.52b | 1.23–6.21b | 0.007b |
| 1.97c | 1.10–3.38c | 0.013c | ||||
|
Tumour size | ||||||
| ⩽3 cm | 1.00 | 1.00 | ||||
| >3 cm | 1.79 | 0.963–3.89 | 0.069 | 1.98b | 0.905–5.93b | 0.086b |
|
Nodal status | ||||||
| Lymph node negative | 1.00 | 1.00 | ||||
| Lymph node positive | 1.51 | 0.922–2.62 | 0.100 | 0.475b | 0.162–1.43b | 0.096b |
|
pTNM stage | ||||||
| I | 1.00 | 1.00 | ||||
| II–IV | 1.89 | 1.21–3.23 | 0.011 | 2.83b | 1.08–8.69b | 0.014b |
| 1.73c | 0.978–3.36c | 0.065c | ||||
|
Differentiation | ||||||
| Moderately/well | 1.00 | |||||
| Poor | 2.12 | 1.24–3.85 | 0.006 | 2.20b | 1.09–5.52b | 0.023b |
| 1.74c | 0.942–3.55c | 0.054c | ||||
|
Histotype | ||||||
| SCC | 1.00 | |||||
| ADC | 1.11 | 0.654–1.97 | 0.674 | 1.19b | 0.593–2.46b | 0.578b |
| Age (continuous) | 0.989 | 0.967–1.01 | 0.352 | 0.977b | 0.951–1.01b | 0.077b |
|
Gender | ||||||
| Male | 1.00 | |||||
| Female | 0.844 | 0.443–1.56 | 0.579 | 1.102b | 0.445–3.13b | 0.798b |
Abbreviations: ADC=adenocarcinoma; CI=confidence interval; HR=hazards ratio; NSCLC=non-small cell lung cancer; OS=overall survival; pTNM=postsurgical pathologic tumour node metastasis; SCC=squamous cell carcinoma.
a
On the basis of 1000 bootstrap samples and following the Bias corrected and accelerated (BCa) approach.
b
Standardised model: includes all variables reported in the univariate analysis.
c
Final model: includes miR-197, pTNM stage and differentiation status.