Table 1. Age-standardiseda risk (with 95% confidence interval) of breast cancer in women with NF1 and in the female population in the United Kingdom by age group.
| Age in years | No. of cases of breast cancer in the NF1 cohort | Relative risk (95% CI) | Absolute risk per year in women in the United Kingdomb | Estimated absolute risk per year in women with NF1c |
|---|---|---|---|---|
| 30–39 | 7 | 6.5 (2.6–13.5) | 1 In 2337 | 1 In 359 (173, 899) |
| 40–49 | 17 | 4.4 (2.5–7.0) | 1 In 603 | 1 In 137 (86, 241) |
| 50–59 | 17 | 2.6 (1.5–4.2) | 1 In 363 | 1 In 140 (86, 242) |
| 60–69 | 12 | 1.9 (1.0–3.3) | 1 In 267 | 1 In 140 (81, 267) |
| 70–79 | 3 | 0.8 (0.2–2.2) | 1 In 285 | 1 In 356 (130, 1425) |
Abbreviations: CI=confidence interval; NF1=neurofibromatosis type 1.
a
Standardised for age in 5-year groups within each 10-year age group.
b
On the basis of data from Cancer Research UK, 2014.
c
On the basis of the point estimate, and limits of the confidence interval, in the third column in the table and the CRUK data in the fourth column.