Table 4. Comparisons consistent with published studies, restricted to patients with 1+ anti-diabetic medication prescriptions.
| Cases N=234 (%) | Controls N=835 (%) | Crude ORa 95% CI | Risk factor-adjusted ORb 95% CI | Duration of diabetes-adjusted ORc 95% CI | Risk factor- and duration of diabetes-adjusted ORd 95% CI | |
|---|---|---|---|---|---|---|
| Did not receive metformin (may have received insulin or other OH) | 50 (21.4) | 139 (16.6) | 1.0 (Ref) | 1.0 (Ref) | 1.0 (Ref) | 1.0 (Ref) |
| Received metformin | 184 (78.6) | 696 (83.4) | 0.59 (0.39–0.90) | 0.88 (0.54–1.46) | 0.60 (0.39–0.93) | 0.92 (0.55–1.54) |
| Did not receive other OH (may have received metformin or insulin) | 46 (19.7) | 247 (29.6) | 1.0 (Ref) | 1.0 (Ref) | 1.0 (Ref) | 1.0 (Ref) |
| Received OH | 188 (80.3) | 588 (70.4) | 1.84 (1.25–2.70) | 1.70 (1.11–2.60) | 1.54 (1.02–2.32) | 1.28 (0.81–2.02) |
| Did not receive insulin (may have received metformin or other OH) | 183 (78.2) | 718 (86.0) | 1.0 (Ref) | 1.0 (Ref) | 1.0 (Ref) | 1.0 (Ref) |
| Received insulin | 51 (21.8) | 117 (14.0) | 1.81 (1.20–2.72) | 1.51 (0.94–2.42) | 1.33 (0.86–2.06) | 1.02 (0.61–1.70) |
Abbreviations: BMI=body mass index; CI=confidence interval; HBV=hepatitis B virus; HCV=hepatitis C virus; OH=oral hypoglycaemic; OR=odds ratio.
a
Conditional on matching factors.
b
Adjusted for BMI, smoking, alcohol-related disorders, HBV or HCV, rare metabolic disorders, statin and paracetamol use, conditional on matching factors.
c
Adjusted for duration of diabetes, conditional on matching factors.
d
Adjusted for BMI, smoking, alcohol-related disorders, HBV or HCV, rare metabolic disorders, statin and paracetamol use, and duration of diabetes, conditional on matching factors.