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. 2014 Aug 19;111(9):1772–1779. doi: 10.1038/bjc.2014.462

Table 2. Statistical performance characteristics of urinary biomarkers to differentiate PDAC from controls.

Biomarker Sensitivity (%) Specificity (%) AUC 95% CI
uMMP-2a 70 85 0.784 0.701–0.870
uTIMP-1a 90 70 0.803 0.723–0.883
uMMP-2a/uTIMP-1a 91 75 0.861 0.790–0.937

Abbreviations: AUC=area under the curve; CI=confidence interval; PDAC=pancreatic ductal adenocarcinoma; ROC=receiver operating characteristic; uMMP-2=urinary matrix metalloprotease-2; uTIMP-1= urinary tissue inhibitor of metalloprotease-1.

a

Cutoff values for MMP-2 (>1.1 ng ml–1) and TIMP-1 (>0.9 ng ml–1) were identified using the Youden index in ROC analysis to compute sensitivity and specificity, respectively.