Table 3. Aspirin use and UADT cancer risk by demographic and behavioural factors.
| Characteristics | OR (95% CI) Test for heterogeneity P-value |
|---|---|
|
Gender | |
| M | 1.02 (0.86, 1.22)a |
| F | 0.72 (0.56, 0.91) P=0.019 |
|
Age (years) | |
| 18–55 | 0.78 (0.46, 1.32)b |
| 56–65 | 0.91 (0.68, 1.21) |
| 66–75 | 0.96 (0.77, 1.19) |
| 76+ | 0.81 (0.64, 1.02) P=0.269 |
|
Carstairs deprivation category | |
| 1 (Least deprived) | 0.90 (0.45, 1.77) |
| 2 | 0.86 (0.53, 1.41)b |
| 3 | 0.94 (0.69, 1.40) |
| 4 | 0.87 (0.68, 1.10) |
| 5 | 0.77 (0.55, 1.08) |
| 6 | 1.14 (0.78, 1.69) |
| 7 (Most deprived) | 0.85 (0.57, 1.27) P=0.438 |
|
Body mass index | |
| 30.0–54.0 | 1.08 (0.77, 1.50)b |
| 25.0–29.9 | 1.32 (1.02, 1.71) |
| 18.5–24.9 | 0.88 (0.66, 1.17) |
| 15.5–18.4 | 0.75 (0.13, 4.26) P=0.164 |
| Missing | 0.65 (0.51, 0.84) |
|
Smoking | |
| Never | 1.00 (0.76. 1.32)b |
| Ever | 0.88 (0.74, 1.05) P=0.108 |
| Missing | 0.54 (0.37, 0.79) |
|
Alcohol consumption | |
| No or low(within recommended limits) | 0.97 (0.82, 1.15)b |
| High (above recommended limits) | 0.92 (0.62, 1.37) P=0.978 |
| Missing | 0.74 (0.56, 0.97) |
Abbreviations: CHD=coronary heart disease; CI=confidence interval; F=female; M=male; NSAID=non-steroidal anti-inflammatory drug; OR=odds ratio; UADT=upper aerodigestive tract cancer.
a
From conditional logistic regression adjusted for deprivation, CHD, stroke and other NSAIDs.
b
From unconditional logistic regression adjusted for age, gender, deprivation, CHD, stroke and other NSAIDs taking into account aggregation within medical practices.