Table 2. Copy-number variation status of KRAS, MYC, CDKN2A and SMAD4 genes in 29 human pancreatic cancer cell lines with MEK162 IC50 values.
| Chr name | chr12 | chr8 | chr9 | chr18 | |||
| Cytoband | p12.1 | q24.21 | p21.3 | q21.2 | |||
| Start | 25259753 | 128818041 | 21958041 | 46814353 | |||
| Stop | 25259812 | 128818100 | 21958099 | 46814412 | |||
| Cell line | IC50 (μM) | KRAS mut | S/R | KRAS | MYC | CDKN2A | SMAD4 |
| PANC 05.04 | 0.00 | 35G>A | S | 0.00 | 0.00 | −2.38 | −4.15 |
| MIAPaCa 2 | 0.01 | 34G>T | S | 0.00 | 0.53 | −3.15 | 0.00 |
| ASPC1 | 0.03 | 35G>A | S | 0.00 | 0.50 | −1.46 | −1.42 |
| HS-766T | 0.03 | WT | S | 0.00 | 0.00 | −3.77 | |
| CAPAN-2 | 0.03 | 35G>T | S | 0.00 | 0.00 | −0.89 | −0.85 |
| PANC 02.03 | 0.03 | 35G>A | S | 0.00 | 0.92 | −0.86 | −0.90 |
| HUP-T4 | 0.03 | 35G>T | S | 0.00 | 0.00 | −2.11 | 0.00 |
| SU 86.86 | 0.08 | 35G>A | S | 1.30 | 0.00 | −3.73 | −1.40 |
| MUT-J | 0.19 | WT | S | 0.00 | 0.00 | 0.00 | −0.91 |
| PSN-1 | 0.20 | 34G>C | S | 2.70 | 5.47 | −1.37 | −4.03 |
| SW1990 | 0.22 | 35G>A | S | 0.00 | 0.00 | −2.70 | −1.35 |
| HPAC | 0.22 | 35G>A | S | 0.00 | 0.00 | 0.00 | −0.53 |
| BXPC3 | 0.24 | WT | S | 0.00 | 0.00 | −3.19 | −4.36 |
| HUP-T3 | 0.38 | 34G>C | S | 0.00 | 2.06 | −2.20 | 0.00 |
| PANC 10.05 | 0.42 | 35G>A | S | 0.00 | 0.85 | 0.00 | −0.52 |
| PL-45 | 0.56 | 35G>A | R | 0.00 | 0.52 | 0.00 | −0.88 |
| HPAF-2 | 0.74 | 35G>A | R | 1.78 | 0.53 | 0.00 | 0.00 |
| PATU 8902 | 0.78 | 35G>T | R | 1.27 | 0.82 | 0.00 | −0.89 |
| PANC 04.03 | 0.82 | 35G>A | R | 0.00 | 0.00 | −0.51 | −1.41 |
| PANC 03.27 | 0.84 | 35G>T | R | 0.56 | 0.00 | −2.93 | −2.73 |
| PATU 8988S | 1.41 | 35G>T | R | −0.79 | 0.00 | −1.68 | −4.57 |
| PANC 08.13 | 1.41 | 35G>A | R | 0.72 | 1.15 | −2.24 | −0.78 |
| CAPAN-1 | 3.32 | 35G>T | R | 0.00 | 1.34 | −2.93 | −0.53 |
| HS-700T | 3.49 | WT | R | 0.00 | 2.32 | 0.00 | 0.00 |
| PANC-1 | 4.42 | 35G>A | R | 0.90 | 0.00 | −2.95 | −0.50 |
| YAP-C | 5.07 | 35G>T | R | 1.11 | 0.00 | −3.33 | −1.70 |
| DAN-G | 6.18 | 35G>T | R | 1.55 | 0.00 | −3.75 | −0.62 |
| CF-PAC 1 | 8.53 | 35G>T | R | 0.51 | 0.88 | −0.86 | −4.86 |
| PATU 8988T | 10.00 | 35G>T | R | −0.53 | 0.00 | −0.61 | −4.52 |
| P-value | 0.02 | 0.715 | 0.99 | 1.00 |
Abbreviation: S/R=sensitive/resistant.
Bold=significant copy-number variations (copy-number gains (1>log2ratio>0.5), amplification (2>log2ration>1), high amplification (log2ratio>2), hemizygous deletions (−0.8<log2ratio<−1), homozygous deletions (log2ratio<−2)), KRAS mut=KRAS mutations at codon 12.