Table 1. Characteristics of patients diagnosed with malignant pleural mesothelioma compensated for occupational asbestos exposure in New South Wales, 2002–2009 (n=910), by patient characteristics.
| Number (value) | % | |
|---|---|---|
|
Demographic characteristics | ||
|
Sex | ||
| Male | 92 | 90 |
| Female | 818 | 10 |
| Median age at diagnosis | (72 years of age) | — |
|
Smoking status | ||
| Never smoker | 302 | 33 |
| Ex/current smoker | 464 | 51 |
| Missing status | 144 | 16 |
|
Asbestos exposure | ||
| Median age at first exposure | 18 years of age | — |
| Median cumulative asbestos exposurea | 24 years | — |
|
Geographic location at the time of diagnosis | ||
| Major city | 605 | 67 |
| (Inner or outer) Regional | 302 | 33 |
| Remote | 3 | <1 |
|
Clinical and pathological characteristics | ||
|
ECOG status | ||
| 0 | 14 | 2 |
| ⩾1 | 776 | 85 |
| Missing | 120 | 14 |
|
Calretinin expression | ||
| Positive expression | 681 | 75 |
| Negative expression | 64 | 7 |
| Testing not performed | 165 | 18 |
|
Clinical stage at diagnosisb | ||
| Early stage disease (Stages X, I–II) | 377 | 42 |
| Late stage disease (Stages III–IV) | 404 | 44 |
| CT data not available | 129 | 14 |
|
NLR | ||
| <5 | 530 | 58 |
| ⩾5 | 316 | 35 |
| Missing | 64 | 7 |
|
Haemoglobin (from baseline) | ||
| <1g dl−1 | 211 | 23 |
| ⩾1g dl−1 | 637 | 70 |
| Missing | 62 | 7 |
|
Platelets ( × 109 l−1) | ||
| <400 | 613 | 67 |
| ⩾400 | 232 | 26 |
| Missing | 65 | 7 |
|
Albumin | ||
| ⩾35g dl−1 | 382 | 42 |
| <35g dl−1 | 281 | 31 |
| Missing | 247 | 27 |
|
White cell count | ||
| <8.3 | 394 | 43 |
| ⩾8.3 | 453 | 50 |
| Missing | 63 | 7 |
|
Tumour characteristics | ||
|
Histological subtype | ||
| Epithelioid | 545 | 60 |
| Biphasic | 119 | 13 |
| Sarcomatoid | 153 | 17 |
| Missing values | 93 | 10 |
|
Treatment characteristics | ||
|
Chemotherapy | ||
| Received chemotherapy | 375 | 41 |
| Received pemetrexed | 344 | 38 |
| Did not receive chemotherapy | 474 | 52 |
| Missing data | 61 | 7 |
|
Surgery | ||
| Underwent EPP | 59 | 7 |
| Did not undergo EPP | 851 | 93 |
| Missing | 1 | 0 |
|
Radiotherapy | ||
| Adjuvant radiotherapy performed | 37 | 4 |
| Adjuvant radiotherapy not performed | 803 | 88 |
| Missing | 71 | 8 |
|
Outcome characteristics | ||
| Median overall survival | 10.0 months | — |
| EORTC Prognostic Score | — | |
| <3 | 305 | 34 |
| ⩾3 | 468 | 51 |
| Missing | 137 | 15 |
Abbreviations: ECOG=Eastern Cooperative Oncology Group; EORTC=European Organisation for Research and Treatment of Cancer; EPP=extrapleural-pneumonectomy; NLR=neutrophil–lymphocyte ratio.
a
Estimated using data of a patients' first age at asbestos exposure and occupational history.
b
Categorised by clinical investigators on this study using CT scan data grouped by the AJCCC criteria.