Table 2. Unadjusted and adjusted estimates of the relative risk of CIN 1, 2 and 3 by number of vaccinations.
Unadjusted estimates |
Adjusteda
estimates |
Unadjusted estimates |
Adjusteda
estimates |
Unadjusted estimates |
Adjusteda
estimates |
|||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
RR | 95% CI | P-value | RR | 95% CI | P-value | RR | 95% CI | P-value | RR | 95% CI | P-value | RR | 95% CI | P-value | RR | 95% CI | P-value | |||
CIN 1 | CIN 2 | CIN 3 | ||||||||||||||||||
Unvaccinated | 1 | 1 | 1 | 1 | 1 | 1 | ||||||||||||||
1 Dose | 1.33 | 0.81, 2.18 | 0.253 | 0.98 | 0.59, 1.63 | 0.9491 | 1.31 | 0.8, 2.15 | 0.277 | 1.03 | 0.62, 1.71 | 0.9182 | 1.89 | 1.2, 2.97 | 0.0061 | 1.42 | 0.89, 2.28 | 0.1445 | ||
2 Doses | 0.9 | 0.59, 1.37 | 0.632 | 0.65 | 0.42, 1.01 | 0.0557 | 1.05 | 0.71, 1.55 | 0.8 | 0.81 | 0.54, 1.22 | 0.3203 | 1.03 | 0.67, 1.58 | 0.9064 | 0.77 | 0.49, 1.21 | 0.25 | ||
3 Doses | 1 | 0.87, 1.16 | 0.962 | 0.71 | 0.58, 0.87 | 0.0008 | 0.64 | 0.54, 0.77 | <0.0001 | 0.5 | 0.40, 0.63 | <0.0001 | 0.59 | 0.48, 0.72 | <0.0001 | 0.45 | 0.35, 0.58 | <0.0001 | ||
1988 | 1 | — | 1 | — | 1 | — | 1 | — | ||||||||||||
1989 | 1 | 0.89, 1.13 | 0.9531 | 0.86 | 0.76, 0.97 | 0.0184 | 1.01 | 0.9, 1.14 | 0.872 | 0.86 | 0.76, 0.97 | 0.0167 | 0.95 | 0.84, 1.09 | 0.489 | 0.84 | 0.73, 0.96 | 0.0098 | ||
1990 | 1.18 | 1.04, 1.34 | 0.0112 | 0.93 | 0.81, 1.07 | 0.2852 | 0.95 | 0.83, 1.09 | 0.479 | 0.78 | 0.67, 0.90 | 0.0005 | 1.01 | 0.87, 1.16 | 0.923 | 0.89 | 0.76, 1.04 | 0.1488 | ||
1991 | 1.18 | 1.01, 1.38 | 0.0379 | 0.82 | 0.67, 1.01 | 0.061 | 0.89 | 0.75, 1.06 | 0.189 | 0.74 | 0.59, 0.91 | 0.0052 | 0.94 | 0.78, 1.13 | 0.508 | 0.86 | 0.68, 1.08 | 0.2034 | ||
1992 | 1.3 | 1.03, 1.66 | 0.0306 | 0.66 | 0.50, 0.89 | 0.0059 | 0.98 | 0.75, 1.28 | 0.902 | 0.58 | 0.42, 0.79 | 0.0006 | 0.78 | 0.57, 1.08 | 0.139 | 0.49 | 0.34, 0.71 | 0.0002 | ||
SIMD 1 | 1 | — | 1 | — | 1 | — | 1 | — | ||||||||||||
SIMD 2 | 0.83 | 0.72, 0.95 | 0.0087 | 0.84 | 0.73, 0.96 | 0.0112 | 0.83 | 0.72, 0.94 | 0.0041 | 0.84 | 0.73, 0.95 | 0.0071 | 0.94 | 0.82, 1.08 | 0.386 | 0.95 | 0.83, 1.10 | 0.4922 | ||
SIMD 3 | 0.83 | 0.72, 0.96 | 0.011 | 0.84 | 0.73, 0.97 | 0.0174 | 0.67 | 0.58, 0.78 | <0.0001 | 0.69 | 0.60, 0.80 | <0.0001 | 0.64 | 0.54, 0.75 | <0.0001 | 0.66 | 0.56, 0.77 | <0.0001 | ||
SIMD 4 | 0.8 | 0.69, 0.93 | 0.0035 | 0.82 | 0.70, 0.94 | 0.0066 | 0.62 | 0.53, 0.72 | <0.0001 | 0.64 | 0.55, 0.74 | <0.0001 | 0.59 | 0.5, 0.7 | <0.0001 | 0.61 | 0.52, 0.73 | <0.0001 | ||
SIMD 5 | 0.74 | 0.64, 0.86 | 0.0001 | 0.76 | 0.66, 0.88 | 0.0002 | 0.45 | 0.39, 0.53 | <0.0001 | 0.47 | 0.40, 0.56 | <0.0001 | 0.45 | 0.38, 0.54 | <0.0001 | 0.47 | 0.40, 0.57 | <0.0001 |
Abbreviations: CI=confidence interval; CIN=cervical intraepithelial neoplasia; RR=relative risk; SIMD=Scottish Index of Multiple Deprivation.
Adjusted for cohort year, SIMD and age in months (time-dependent covariate – not shown). Bold indicates these variables being statistically significant, that is, P<0.05.