Table 2. Unadjusted and adjusted estimates of the relative risk of CIN 1, 2 and 3 by number of vaccinations.

	Unadjusted estimates			Adjusteda estimates				Unadjusted estimates			Adjusteda estimates				Unadjusted estimates			Adjusteda estimates
	RR	95% CI	P-value	RR	95% CI	P-value		RR	95% CI	P-value	RR	95% CI	P-value		RR	95% CI	P-value	RR	95% CI	P-value
CIN 1							CIN 2							CIN 3
Unvaccinated	1			1				1			1				1			1
1 Dose	1.33	0.81, 2.18	0.253	0.98	0.59, 1.63	0.9491		1.31	0.8, 2.15	0.277	1.03	0.62, 1.71	0.9182		1.89	1.2, 2.97	0.0061	1.42	0.89, 2.28	0.1445
2 Doses	0.9	0.59, 1.37	0.632	0.65	0.42, 1.01	0.0557		1.05	0.71, 1.55	0.8	0.81	0.54, 1.22	0.3203		1.03	0.67, 1.58	0.9064	0.77	0.49, 1.21	0.25
3 Doses	1	0.87, 1.16	0.962	0.71	0.58, 0.87	0.0008		0.64	0.54, 0.77	<0.0001	0.5	0.40, 0.63	<0.0001		0.59	0.48, 0.72	<0.0001	0.45	0.35, 0.58	<0.0001
1988	1	—		1	—						1	—						1	—
1989	1	0.89, 1.13	0.9531	0.86	0.76, 0.97	0.0184		1.01	0.9, 1.14	0.872	0.86	0.76, 0.97	0.0167		0.95	0.84, 1.09	0.489	0.84	0.73, 0.96	0.0098
1990	1.18	1.04, 1.34	0.0112	0.93	0.81, 1.07	0.2852		0.95	0.83, 1.09	0.479	0.78	0.67, 0.90	0.0005		1.01	0.87, 1.16	0.923	0.89	0.76, 1.04	0.1488
1991	1.18	1.01, 1.38	0.0379	0.82	0.67, 1.01	0.061		0.89	0.75, 1.06	0.189	0.74	0.59, 0.91	0.0052		0.94	0.78, 1.13	0.508	0.86	0.68, 1.08	0.2034
1992	1.3	1.03, 1.66	0.0306	0.66	0.50, 0.89	0.0059		0.98	0.75, 1.28	0.902	0.58	0.42, 0.79	0.0006		0.78	0.57, 1.08	0.139	0.49	0.34, 0.71	0.0002
SIMD 1	1	—		1	—						1	—						1	—
SIMD 2	0.83	0.72, 0.95	0.0087	0.84	0.73, 0.96	0.0112		0.83	0.72, 0.94	0.0041	0.84	0.73, 0.95	0.0071		0.94	0.82, 1.08	0.386	0.95	0.83, 1.10	0.4922
SIMD 3	0.83	0.72, 0.96	0.011	0.84	0.73, 0.97	0.0174		0.67	0.58, 0.78	<0.0001	0.69	0.60, 0.80	<0.0001		0.64	0.54, 0.75	<0.0001	0.66	0.56, 0.77	<0.0001
SIMD 4	0.8	0.69, 0.93	0.0035	0.82	0.70, 0.94	0.0066		0.62	0.53, 0.72	<0.0001	0.64	0.55, 0.74	<0.0001		0.59	0.5, 0.7	<0.0001	0.61	0.52, 0.73	<0.0001
SIMD 5	0.74	0.64, 0.86	0.0001	0.76	0.66, 0.88	0.0002		0.45	0.39, 0.53	<0.0001	0.47	0.40, 0.56	<0.0001		0.45	0.38, 0.54	<0.0001	0.47	0.40, 0.57	<0.0001

Abbreviations: CI=confidence interval; CIN=cervical intraepithelial neoplasia; RR=relative risk; SIMD=Scottish Index of Multiple Deprivation.

^aAdjusted for cohort year, SIMD and age in months (time-dependent covariate – not shown). Bold indicates these variables being statistically significant, that is, P<0.05.