Table 5. Research indices in 32 patients in Group 2 (surgery followed by standard chemotherapy).
| Baseline | 3 months | 6 months | P-value | |
|---|---|---|---|---|
| Circulating endothelial cells (cells ml−1) | 12 (0–19) | 3 (0–11) | 10 (0–12) | 0.019a |
| Endothelial progenitor cells (cells ml−1) | 16 (9–44) | 0 (0–11) | 10 (8–15) | <0.001b |
| Von Willebrand factor (IU dl−1) | 123 (33) | 106 (25) | 119 (28) | 0.08 |
| Soluble E selectin (ng ml−1) | 34 (12) | 38 (9) | 24 (10) | 0.007c |
| VEGF (pg ml−1) | 320 (30–1200) | 30 (20–287) | 30 (21–310) | 0.001d |
| Angiogenin (ng ml−1) | 282 (97) | 231 (93) | 346 (109) | <0.001e |
| CD34+ve cells (cells ml−1) | 781 (417–1315) | 839 (583–1212) | 686 (361–1056) | 0.304 |
| White cell count (x106 ml−1) | 7.9 (2.2) | 5.4 (1.3) | 5.8 (2.0) | <0.001d |
Data are mean (s.d.) or median (interquartile range). P-value by ANOVA/general linear model/Tukey's post hoc test.
a
P<0.05, baseline to 3-month point.
b
P<0.01, baseline to 3 months, P<0.05, 3 months to 6 months.
c
P<0.05, 3 months to 6 months.
d
P<0.01, baseline to 3 months and to 6 months.
e
P<0.05, baseline to 6 months, P<0.01, 3 months to 6 months.