Table 6. Research indices in 20 patients in Group 3 (surgery followed by standard chemotherapy and antiangiogenic therapy).
| Baseline | 3 months | 6 months | P-value | |
|---|---|---|---|---|
| Circulating endothelial cells (cells ml−1) | 21 (7–60) | 0 (0–13) | 11 (7–48) | 0.005a |
| Endothelial progenitor cells (cells ml−1) | 21 (10–39) | 0 (0–0) | 12 (7–32) | <0.001b |
| Von Willebrand factor (IU dl−1) | 121 (30) | 122 (26) | 122 (15) | 0.943 |
| Soluble E selectin (ng ml−1) | 26 (8) | 22 (15) | 29 (12) | 0.195 |
| VEGF (pg ml−1) | 500 (40–1000) | 30 (23–55) | 770 (630–1900) | <0.001b |
| Angiogenin (ng ml−1) | 319 (97) | 255 (117) | 317 (87) | 0.074 |
| CD34+ve cells (cells ml−1) | 781 (585–1123) | 595 (427–1139) | 291 (192–535) | 0.003c |
| White cell count (x106 ml−1) | 6.7 (1.5) | 5.1 (1.7) | 5.3 (1.4) | 0.003d |
Data are mean (s.d.) or median (interquartile range).
a
P<0.01, baseline to 3 months, P<0.05, 3 months to 6 months.
b
P<0.01, baseline to 3 months and baseline to 6 months.
c
P<0.01, baseline to 6 months.
d
P<0.01, baseline to 3 months, P<0.02, baseline to 6 months.