Table 3. Univariate analysis for PFS and OS.

	Hazard ratio	95% CI	P-value
PFS
PKM2 expression (high vs low)	1.89	1.48–2.27	0.003
PS (2 vs 0–1)	2.64	1.89–3.17	0.001
Age (>70 vs ⩽70 years)	1.24	0.87–1.62	0.77
Gender (male vs female)	1.19	0.84–1.41	0.51
Stage (IV vs IIIB)	1.77	1.11–2.31	0.03
Histology (squamous vs non-squamous)	1.32	0.85–1.54	0.61
Tumour differentiation (low vs well-moderate)	1.41	0.90–1.77	0.14
OS
PKM2 expression (high vs low)	1.93	1.54–2.46	0.002
PS (2 vs 0–1)	2.87	1.92–3.44	<0.001
Age (>70 vs ⩽70 years)	1.35	0.91–1.88	0.23
Gender (male vs female)	1.16	0.81–1.33	0.48
Stage (IV vs IIIB)	1.45	0.96–1.85	0.17
Histology (squamous vs non-squamous)	1.17	0.89–1.28	0.94
Tumour differentiation (low vs well-moderate)	1.32	0.87–1.32	0.31

Abbreviations: CI=confidence interval; OS=overall survival; PFS=progression-free survival; PS=performance status.