Table 4. Multivariate analysis for PFS and OS.

	Hazard ratio	95% CI	P-value
PFS
PKM2 expression (high vs low)	1.81	1.40–2.38	0.002
PS (2 vs 0–1)	3.97	2.77–4.16	<0.001
Stage (IV vs IIIB)	1.34	0.96–1.88	0.13
OS
PKM2 expression (high vs low)	1.97	1.45–2.46	0.001
PS (2 vs 0–1)	4.01	3.56–5.06	<0.001

Abbreviations: CI=confidence interval; OS=overall survival; PFS=progression-free survival; PS=performance status.